Tissue damage from chemical burns depends on several factors. The strength or focus of the agent The website of contact Whether swallowed or inhaled Whether skin is intact With the number of the chemical The duration of exposure The way the chemical works The length of time to washing Signs and symptoms of chemical substance burns are the following: Redness, irritation, or burning up at the website of contact Pain or numbness at the site of contact Development of blisters or dark dead skin at the contact site Vision adjustments if the chemical gets into the eyes Cough or shortness of breath Vomiting In severe cases, a person may develop the following symptoms: Low blood pressure Faintness, weakness, dizziness Shortness of breath or severe cough Headache Muscle twitching or seizures Cardiac arrest or irregular heartbeat Chemical substance burns can be very unpredictable.Median follow-up time for the sufferers was 3.2 years, of which point 22 % of individuals skilled disease recurrence or loss of life. There were no significant differences observed in survival outcomes with respect to BRCA status and kind of neoadjuvent chemotherapy received. Regarding to Arun, there is absolutely no consensus on the most effective chemotherapy regimen for treating ladies who carry the BRCA mutation, because of a lack of prospective studies. This brand-new insight tempts us to take a position that the current presence of the BRCA1 mutation determines how some ladies will react to neoadjuvent chemotherapy.