Today in EBioMedicine according to a landmark study published.

Cancer Research UK researchers identify five distinct types of prostate cancer Cancer Research UK researchers have for the first time identified that there are five distinct types of prostate cancers and found a method to distinguish between them, today in EBioMedicine according to a landmark study published. The results could have important implications for how doctors treat prostate cancer in the future, by determining tumours that will grow and spread aggressively through the body. The experts, from the Cancer Study UK Cambridge Institute and Addenbrooke's Hospital, studied samples of cancerous and healthy prostate tissue from a lot more than 250 men . By looking for abnormal chromosomes and calculating the experience of 100 different genes from the disease they were in a position to group the tumours into five distinct types, each with a characteristic genetic fingerprint. This analysis was better at predicting which cancers were apt to be the most aggressive than the tests currently utilized by doctors – including the PSA test and Gleason rating. But, the findings need to be verified in clinical trials with larger sets of men. Related StoriesFDA grants accelerated authorization for Tagrisso to treat patients with advanced NSCLCOvarian malignancy patients with a brief history of oral contraceptive use have better outcomesMD Anderson study reveals why chemotherapy medicines not effective for most pancreatic cancer patientsStudy writer Dr Alastair Lamb, from the Tumor Analysis UK Cambridge Institute, stated: ‘Our exciting results display that prostate cancer could be categorized into five genetically-different types. These findings may help doctors decide on the best training course of treatment for each individual patient, based on the characteristics of their tumour. ‘The next step is to verify these results in bigger studies and drill into the molecular 'nuts and bolts' of every specific prostate cancer type. By carrying out more research into how the different illnesses behave we might have the ability to develop far better methods to treat prostate cancers patients in the future, saving even more lives.’ Prostate cancer is the most common tumor in men in the united kingdom, with around 41,700 cases diagnosed every full year. There remain 10,800 deaths from the condition each full year in the united kingdom. Professor Malcolm Mason, Cancers Study UK's prostate cancer expert, said: ‘The challenge in treating prostate tumor is that it could either behave like a pussycat – developing slowly and unlikely to cause complications in a man's lifetime – or a tiger – spreading and requiring urgent treatment aggressively. But at the moment we have no reliable way to distinguish them. Which means that some men may get treatment they don't need, causing needless side effects, while others might benefit from more intensive treatment. ‘This research could possibly be game-changing if the outcomes endure in larger scientific trials and may give us better info to guide each man's treatment – even helping us to select between treatments for males with aggressive cancers. Eventually this could mean far better treatment for the guys who need it, helping to save more lives and improve the quality of lifestyle for many a large number of men with prostate cancers.’.

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Canada spends even more on stem cell research Canadian Justice Minister Irwin Cotler gave Canadian stem cell research an extra boost with the announcement of $5.3 million in annual funding. The study financing for the Stem Cell Network will support several national projects, including an effort led by Dr. Jacques Galipeau of the Montreal-based Jewish General Medical center to study the usage of adult stem cells as restoration material to greatly help sufferers with cardiovascular and respiratory diseases. Related StoriesSCT, Thermo Fisher Scientific collaborate to progress development of cardiac disease modelsUS and German experts team up to progress quality control of human stem cellsNYSCF conference to spotlight translational stem cell and neuroscience researchResearchers are optimistic that stem cells, that exist in fat, blood, bone and cells themselves, will be used to correct damaged hearts eventually, blood and lungs vessels. Stem cells are like ‘seeds’ and may be utilized ‘to grow a crop of brand-new tissue,’ says Galipeau, which could be used to correct and restore damaged tissue. He wants to bring these technologies to real people. Scientists in Canada can use adult and embryonic stem cells for analysis but can’t legally press the limits any more. Discussing the production and then destruction of week-outdated embryos to harvest stem cells, Galipeau says there is absolutely no therapeutic cloning allowed in Canada. This spring Later, Galipeau and Toronto-based Dr. Duncan Stewart of St. Michael’s Hospital could have sufferers in the late levels of the pulmonary arterial hypertension disease, who are awaiting life-saving transplants, take part in a trial that will attempt to combine stem cells and gene therapy to treat it. Researchers from Montreal, Toronto, Vancouver and Ottawa wish to have medical trials within the next two to five years with sufferers using their personal stem cells to repair damaged hearts and lungs. Cotler called it a ‘landmark day’ for medical research and health care, noting that Canada is among the leaders in stem cell research.