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In comparison, mast cells, which co-exhibit the markers CD68 and CD117, were significantly expanded in mere GFP-positive bone marrow and spleen cells of transplanted pets. Analysis of mononuclear cells from chronic phase CML sufferers showed that this B-cell-differentiation block can be a feature of human disease. Additionally, CD3+ individual T cells were considerably increased in the spleen of transplanted mice, both in cells expressing rather than expressing GFP, but this growth of T cells was noticed only in GFP-bad bone marrow cells. Fioretos et al remember that the expansion of macrophages/histiocytes and T cells is usually indicative of an inflammatory response. Licensed from medwireNews with authorization from Springer Healthcare Ltd.