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Some patients with ischemic stroke are treated quickly with intravenous recombinant tissue plasminogen activator , which works to help dissolve the clot and reopen the artery. Nevertheless, some patients usually do not respond to rtPA only, according to background info in this article. In animals, argatroban–which blocks the action of chemical substances that clot the blood–has been shown to work with rtPA, increasing blood flow, speeding the opening of arteries and preventing recurring blockages. Argatroban is usually approved for use in patients with heart attacks to greatly help prevent clots but has not been tested in human being stroke victims. Rebecca M. Sugg, M.D., University of Texas-Houston Medical School, and co-workers evaluated the safety and efficacy of the drug combination in 15 stroke patients who got blockages in the cerebral arteries, major blood vessels leading to the brain.