Li, If we are able to discover the pathogenesis for Huntington’s disease, or if we realize how the mutant huntingtin impacts the transporting inside cells, maybe then we can find some effective treatment to avoid this type or sort of defect. Research into various other neurodegenerative disorders may also benefit from an intensive understanding of HAP1. This work also has implications for understanding the standard physiological processing for neuronal functioning, says Dr. Li.. Cause of neurodegeneration in Huntington’s disease discovered The severe neurodegeneration connected with Huntington’s disease may result from molecular mutations that block the transport of nutrients within cells. Results from the Emory University College of Medicine suggest that the mutant huntingtin protein limits the initiatives of the huntingtin-associated proteins-1 to supply nutrients to developing neurons, or neurites.The study found that this practical measurement of cholesterol efflux supplied significantly different details than did standard measurements of HDL cholesterol. The findings uncovered a substantial protective relationship between cholesterol efflux and cardiovascular risk. The better a person's cholesterol efflux, the less likely she or he was to suffer a heart attack, stroke, or death from cardiovascular disease. The association was much stronger for cholesterol efflux than for the traditional measurement of HDL cholesterol level. HDL cholesterol has long been considered good cholesterol because numerous populace studies have shown a consistent, strong, inverse relationship between HDL cholesterol levels and threat of heart disease.