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These protein sites seem to be important for the potency of general anesthesia. Johns notes that there’s been a great deal of concern recently that anesthesia in infants and newborns may cause neurotoxicity leading to long-term cognitive complications and impaired learning. The data in rodents, human beings and primates all stage in this direction, and the meals and Drug Administration has simply elevated its level of concern concerning this issue, he says. His research team is currently learning whether anesthetic interactions with PSD95 and other scaffolding proteins are likely involved. We hypothesized that because PSD95 can be involved with neuronal synapse development – – or making the correct connections between neurons as the brain is usually forming – – during fetal and infant brain development, the power of anesthetics to block the actions of PSD scaffolding proteins, as shown inside our new study, may be preventing correct neuronal synapse development, leading to the long-term storage and learning deficits noticed.